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神经管缺陷是最为常见的先天性结构异常性疾病中的一种,它可以表现为先天性脊柱裂及无脑畸形等。导致神经管先天性缺陷的病因中,基因结构异常是一个重要原因,但更为常见的是环境因素。在环境因素中,细胞松弛素、咖啡因、离子载体A23187、罂粟碱、安定、局麻及叶酸缺乏等均可导致神经管缺陷。其中,在治疗癫痫中常用的苯妥因对神经管缺陷的作用较为肯定。为了了解叶酸在抑制苯妥因导致的鸡胚神经管缺陷中的作用,该文作者通过光镜、投射电镜及组织病理学等手段对处于第8阶段的HubbardBroil鸡胚的神经管的作用进行了研究。研究结果发现:在空白对照组中,88.6％的鸡胚神经管发育正常,闭合良好;给予苯妥因组中
Neural tube defects are one of the most common congenital structural abnormalities and can manifest as congenital spina bifida and anencephaly. Among the causes of neural tube defects, structural abnormalities are an important cause, but environmental factors are more common. In environmental factors, cytochalasin, caffeine, ionophores A23187, papaverine, diazepam, local anesthesia and folic acid deficiency can lead to neural tube defects. Among them, phenytoin commonly used in the treatment of epilepsy is more certain of the role of neural tube defects. In order to understand the role of folic acid in the inhibition of phenytoin-induced neural tube defects in chicken embryos, the authors performed the neural tube function of Hubbard Broil embryos in stage 8 by light microscopy, transmission electron microscopy and histopathology the study. The results showed that: in the blank control group, 88.6% of chick embryo neural tube normal development, closed well; given phenytoin group