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灌服瑞香素300和600mg/kg能延长断头小鼠张口动作持续时间,延长KCN或NaNO_2中毒小鼠的存活时间,且具有一定的量效关系。瑞香素虽不延长常压密闭缺氧小鼠的存活时间,但能对抗异丙肾上腺素的加速常压密闭缺氧小鼠耗氧速度和缩短存活时间的作用。
Administration of daphnetin at doses of 300 and 600 mg / kg prolonged the duration of mouth opening in severed mice and prolonged the survival time of KCN or NaNO_2 poisoning mice, with a dose-effect relationship. Although daphnetin does not prolong the survival time of hypobaric mice under normal pressure, it can antagonize the action of isoproterenol to accelerate the oxygen consumption rate and shorten the survival time of hypoxic mice.