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目的:探讨消化道肿瘤患者手术前后血清血管内皮生长因子(vascularendothelialgrowthfactor,VEGF)和Endosta-tin的动态变化规律及其与临床病理特征的关系。方法:ELISA法检测胃癌、肝癌、结直肠癌患者术前及术后2周血清VEGF和Endostatin水平,并分别以慢性胃炎、慢性乙型肝炎、结肠腺瘤患者和健康人群作对照。结果:胃癌、肝癌、结直肠癌患者术前血清VEGF和Endostatin水平分别显著高于慢性胃炎、慢性乙型肝炎、结肠腺瘤患者及健康人群组(P<0.01);术前血清VEGF、Endostatin水平与细胞分化程度、肿瘤大小、浸润深度、区域淋巴结转移、远处转移及临床分期密切相关(P<0.05),与性别、肿瘤部位等因素无关(P>0.05);术后2周血清VEGF水平较术前均有显著性下降(P<0.01),而血清Endostatin水平较术前升高(P<0.01)。结论:胃癌、肝癌、结直肠癌患者血清VEGF和Endostatin水平升高,且与肿瘤细胞分化程度、肿瘤大小、浸润深度、区域淋巴结转移、远处转移及临床分期密切相关,它们可推荐作为评价胃癌、肝癌、结直肠癌恶性行为、预测浸润和转移程度的有效指标。
Objective: To investigate the dynamic changes of serum vascular endothelial growth factor (VEGF) and Endosta-tin in patients with gastrointestinal cancer before and after operation and their relationship with clinicopathological features. Methods: Serum levels of VEGF and Endostatin in gastric cancer, liver cancer and colorectal cancer patients before and 2 weeks after surgery were detected by ELISA. Chronic gastritis, chronic hepatitis B, colon adenoma and healthy controls were used as controls. Results: The serum levels of VEGF and Endostatin in patients with gastric cancer, liver cancer and colorectal cancer were significantly higher than those in patients with chronic gastritis, chronic hepatitis B and colon adenoma (P <0.01), respectively. Preoperative serum levels of VEGF and Endostatin The levels were closely related to the degree of cell differentiation, tumor size, depth of invasion, regional lymph node metastasis, distant metastasis and clinical stage (P <0.05), but not with gender, tumor location and other factors (P> 0.05) The level of serum Endostatin was significantly lower than that before operation (P <0.01), while the level of Endostatin in serum was higher than that before operation (P <0.01). Conclusions: Serum levels of VEGF and Endostatin in patients with gastric cancer, liver cancer and colorectal cancer are elevated, and are closely related to the degree of tumor cell differentiation, tumor size, depth of invasion, regional lymph node metastasis, distant metastasis and clinical stage. They can be recommended as indicators for evaluating gastric cancer , Liver cancer, malignancy of colorectal cancer, and prediction of the degree of invasion and metastasis.