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目的探讨羟苯磺酸钙联合缬沙坦治疗老年早期糖尿病肾病的临床效果。方法 2014年4月—2016年4月选取120例老年早期糖尿病肾病患者,随机分为A、B、C三组各40例,三组患者入院后即接受常规糖尿病综合治疗,血糖控制良好后A组给予羟苯磺酸钙治疗,B组给予缬沙坦治疗,C组给予羟苯磺酸钙联合缬沙坦治疗,比较三组治疗效果及相关指标变化情况,数据采用SPSS22.0软件进行统计学处理,P<0.05为差异有统计学意义。结果 A总有效率为72.5%、B组为70.05,均低于C组的90.0%,比较差异均有统计学意义(均P<0.05);A、B两组治疗后尿微量蛋白和尿蛋白排泄率(urinary albumin excretion rate,UAER)水平均高于C组,比较差异均有统计学意义(均P<0.05);A、B两组治疗后血肌酐(serum creatinine,Scr)、血尿素氮(blood urea nitrogen,BUN)、血清内皮素(endothelin,ET)和胱抑素(cyscatin,Cys)C水平水平均高于C组,比较差异均有统计学意义(均P<0.05)。结论羟苯磺酸钙联合缬沙坦治疗老年早期糖尿病肾病效果显著,可有效改善患者肾功能及血管内皮功能。
Objective To investigate the clinical effects of calcium dobesilate and valsartan in the treatment of elderly diabetic nephropathy. Methods From April 2014 to April 2016, 120 elderly patients with early diabetic nephropathy were randomly divided into three groups (A, B and C), 40 patients in each group. The patients in the three groups received routine diabetes mellitus after admission and the blood glucose control was good. A Group were treated with calcium dobesilate, group B was treated with valsartan, group C was given calcium dobesilate combined with valsartan. The treatment effect and the changes of related indexes were compared between the three groups. The data were analyzed by SPSS 22.0 software School processing, P <0.05 for the difference was statistically significant. Results The total effective rate was 72.5% in group A, 70.05 in group B, which was lower than 90.0% in group C (all P <0.05). The urine microalbumin and urinary protein Urinary albumin excretion rate (UAER) levels were higher than those in C group (all P <0.05). Serum creatinine (Scr), blood urea nitrogen blood urea nitrogen (BUN), endothelin (ET) and cyscatin (Cys) C were significantly higher than those in C group (all P <0.05). Conclusion The combination of calcium dobesilate and valsartan in the treatment of early diabetic nephropathy is effective in improving renal function and vascular endothelial function.