Objective: To illustrate the laboratory findings in a patient with bilateral asteroid hyalosiswho presentedwith calcified deposits on a 3- piece silicone intraocular lens (IOL). Design: Observational case report. Methods: A 76- year- old diabetic woman underwent uneventful cataract surgery in 1994 with implantation of a silicone- optic polypropylene- haptic IOL in the left eye. A neodymium:yttrium- aluminum- garnet (Nd:YAG) laser posterior capsulotomy was performed 2 years after cataract surgery, but persistent whitish deposits were observed on the posterior optic surface of the lens. Over the next 3 years, the opacification increased in the region corresponding to the capsulotomy. The IOL was explanted/exchanged. The right eye had cataract surgery in 1995. The acrylic lens implanted in this eye developed no opacities after 6 years. Main Outcome Measures: Gross, microscopic, and surface analyses of the explanted IOL. Results: Gross and light microscopic analyses revealed the presence of confluent crustlike deposits on the central area of the posterior optic surface, as well as Nd:YAG pits. Individual spherules exhibiting a Maltese- cross pattern under polarizing light were also observed. Energy dispersive x- ray spectroscopic analyses demonstrated the composition of the confluent deposits to be similar to hydroxyapatite. Conclusions: An association between asteroid hyalosis and dystrophic calcification of IOLs has been reported only with silicone plate haptic designs. The material opacifying the 3- piece silicone lens probably was derived from the asteroid bodies or from the process that results in this vitreous condition. Clinical evaluation of other pseudophakic patients with asteroid hyalosis will confirm if this phenomenon is restricted to silicone IOLs. Methods: A 76- year- old diabetic woman underwent uneventful cataract surgery in in patients with bilateral asteroid hyalosis who presented with calcified deposits on a 3-piece silicone intraocular lens (IOL). 1994 with implantation of a silicone-optic polypropylene-haptic IOL in the left eye. A neodymium: yttrium-aluminum-garnet (Nd: YAG) laser posterior capsulotomy was performed 2 years after cataract surgery, but persistent whitish deposits were observed on the posterior The ophthalmic surface of the lens. Over the next 3 years, the opacification increased in the region corresponding to the capsulotomy. The IOL was explanted / exchanged. The right eye had cataract surgery in 1995. The acrylic lens implanted in this eye developed no opacities after 6 years. Main Outcome Measures: Gross, microscopic, and surface analyzes of the interpreted IOL. Results: Gross and light microscopic analyzes revealed the presence of o f confluent crustlike deposits on the central area of ​​the posterior optic surface, as well as Nd: YAG pits. Individual spherules exhibiting a Maltese-cross pattern under polarizing light were also observed. Energy dispersive x-ray spectroscopic analyzes demonstrated the composition of the confluent Conclusions: An association between asteroid hyalosis and dystrophic calcification of IOLs has been reported only with silicone plate haptic designs. The material opacifying the 3-piece silicone lens probably derived from the asteroid bodies or from the process that results in this vitreous condition. Clinical evaluation of other pseudophakic patients with asteroid hyalosis will confirm if this phenomenon is restricted to silicone IOLs.