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一些大规模、多中心、前瞻性临床试验已证实,降低血脂尤其是降低低密度脂蛋白胆固醇(LDL-C)能有效防治动脉粥样硬化(AS),阻断其病变进展,甚至有消退斑块作用。但AS斑块的形成和发展涉及多种因素,除脂质代谢紊乱外,还与其它许多机制有关,如血管内皮通透性、血细胞对血管壁的粘附和浸润、血细胞和血管组织衍生的生长因子和细胞因子、血管平滑肌细胞(VSMC)的增殖和迁移、细胞外基质(ECM)的合成和沉积等。在一些采用定量冠状动脉造影判定血管损伤的降脂药物临床试验中,即使血浆
A number of large, multicenter, prospective clinical trials have confirmed that lowering blood lipids, especially LDL-C, is effective in preventing and treating atherosclerosis (AS), blocking the progression of the disease, Block effect. But AS plaque formation and development involves a variety of factors, in addition to lipid metabolism disorder, but also with many other mechanisms, such as vascular endothelial permeability, adhesion and infiltration of blood cells on the vascular wall, blood cells and vascular tissue derived Growth factors and cytokines, proliferation and migration of vascular smooth muscle cells (VSMC), synthesis and deposition of extracellular matrix (ECM) and the like. In some lipid-lowering drug clinical trials that use quantitative coronary angiography to determine vascular injury, even plasma