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目的 探讨组织金属蛋白酶抑制物 (TIMPs)表达与结、直肠癌转移的关系。方法 用免疫组织化学的方法回顾性检测 60例结、直肠肿瘤石蜡标本中TIMP 1,TIMP 2的表达。应用图像分析的方法定量分析TIMP 1、TIMP 2在肿瘤组织及间质中的表达 ,并进一步探讨与肿瘤转移潜能之间的关系。结果 TIMP 1在肿瘤细胞中表达高于间质 (P <0 0 1) ,同时肿瘤细胞TIMP 1表达高于TIMP 2 (P <0 0 1)。无血管转移组TIMP 2表达高于有血管转移组 (P <0 0 1)。腺瘤组织TIMP 1、2表达均高于癌组织 (P <0 0 1)。结论 TIMPs在结直肠癌中的表达与抑制肿瘤转移相关。
Objective To investigate the relationship between the expression of tissue inhibitors of metalloproteinases (TIMPs) and the metastasis of colorectal cancer. Methods The immunohistochemical method was used to detect the expression of TIMP-1 and TIMP-2 in 60 cases of rectal tumor paraffin specimens. Image analysis was used to quantitatively analyze the expression of TIMP-1 and TIMP-2 in tumor tissues and interstitium, and to further explore the relationship between the expression of TIMP-1 and tumor metastasis potential. Results The expression of TIMP-1 in tumor cells was higher than that in stroma (P <0.01), and the expression of TIMP-1 in tumor cells was higher than that in TIMP-2 cells (P <0.01). The expression of TIMP 2 in the avascular group was higher than that in the vascular group (P <0.01). The expression of TIMP-1 in adenoma was higher than that in carcinoma (P <0.01). Conclusion The expression of TIMPs in colorectal cancer is related to the inhibition of tumor metastasis.