红色青霉毒素B(Rubratoxin B,以下简称R)是一种红色青霉菌的代谢产物,在化学结构上具有α-、β-不饱和内脂环。为了确定R的致突变和致畸性及与其相联系的结构,本文作者选用了体重为25～30g的ICR瑞士种小鼠进行实验。给予雄性小鼠腹腔注射R或其氢化同系物连续5天(R组为:0.5和1.5mg/kg,氢化R组为:1.0和10mg/kg),对照组给予赋形剂,然后与未注射R的童鼠交配,持续8周,以发现精子作为妊娠的第1天。全部雌鼠自交配周的中期算起13天后处死。尸解时计算妊娠的雌鼠数和着床总数,包括活胎数、后期胚胎死亡数及早期胚胎死亡数。每周计算一次平均数。本次实验结果发现,R和氢化R的LD_(50)分别为5.6和31.0mg/kg。高剂量的R(1.5mg/kg)和氢化R(10mg/kg)引起小鼠体重下降,低剂量R及氢化R Rubratoxin B (hereinafter referred to as R) is a metabolite of Penicillium funiculosum and has an α-, β-unsaturated alicyclic ring in its chemical structure. In order to determine the mutagenicity and teratogenicity of R and its associated structure, the authors selected ICR Swiss mice weighing 25-30 g for experiments. Male mice were intraperitoneally injected with R or its hydrogenated homologues for 5 days (group R: 0.5 and 1.5 mg / kg, group R: 1.0 and 10 mg / kg), and the control group was given vehicle, R’s pups mated for 8 weeks to find sperm as the first day of pregnancy. All females were sacrificed after 13 days from the middle of mating week. At the time of autopsy, the number of pregnant women and the total number of implants were calculated, including the number of live births, the number of late embryos and the number of early embryos. Calculate the average weekly. The experimental results showed that the LD_ (50) of R and hydrogenated R were 5.6 and 31.0 mg / kg, respectively. High doses of R (1.5 mg / kg) and hydrogenated R (10 mg / kg) caused weight loss in mice, low doses of R and hydrogenated R