二甲亚砜能溶解多种水溶性或脂溶性药物,故称万能溶媒,能增强药物的输送和渗透作用;其本身还具有抗炎、抗菌、解痉、抗凝、脱水和止痛等作用。双氯芬酸,为新型强效非甾体消炎镇痛药,能透过生物膜。以上两种药物并用治疗根尖周炎,因易于通过根管进入根尖周病灶而提高治疗效果。为选择所用药物的最佳浓度,进行临床试验,结果表明,50％的二甲亚砜和2.5％的双氯芬酸并用最为适宜。 治疗急性化脓性根尖周炎和慢性根尖周炎加重期患者68例,年龄16～35岁。患者第1次就诊时,开放牙髓腔,清除崩解的牙髓,用双氯芬酸和二甲亚砜处理 Dimethyl sulfoxide can dissolve a variety of water-soluble or fat-soluble drugs, it said universal solvent, can enhance the drug delivery and infiltration; itself also has anti-inflammatory, antibacterial, antispasmodic, anticoagulant, dehydration and analgesic effect. Diclofenac, a new potent non-steroidal anti-inflammatory analgesic, permeable to biofilms. The above two drugs and the treatment of periapical periodontitis, due to easy access to the periapical lesions through the root canal and improve the therapeutic effect. In order to choose the best concentration of the drug to use, clinical trials have shown that 50% dimethyl sulfoxide and 2.5% diclofenac are most suitable for use. 68 cases of acute suppurative apical periodontitis and chronic apical periodontitis exacerbation, aged 16 to 35 years old. At the first visit of the patient, the dental pulp cavity was opened, the disintegrated pulp was cleared, treated with diclofenac and dimethyl sulfoxide