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目的观察曲美他嗪(TMZ)对不稳定型心绞痛(UA)患者左室功能的影响及临床疗效,为临床上治疗UA提供理论依据。方法选取2005年12月-2010年12月住院的不稳定心绞痛患者共107例,随机分为观察组(n=53)和对照组(n=54)。对照组接受常规抗不稳型心绞痛药物治疗,包括硝酸酯类、β-受体阻滞剂、钙离子拮抗剂、抗凝、抗血小板药物等,观察组在常规治疗基础上加用曲美他嗪片20mg/次,3次/d,共12w。治疗前、后用彩色多普勒超声仪进行心脏功能检查,并测量左室舒张末期内径和收缩末期内径(LVEDD,LVESD)、左室射血分数(LVEF)、舒张早期和舒张晚期血流峰值之比(E/A)等参数。结果治疗后观察组总有效率为90.57%,对照组总有效率为75.93%,两组比较差异明显(χ2=4.10,P<0.05)。观察组患者与对照组比较,左室LVEDD、LVESD降低和LVEF、E/A的升高有显著性差异(P<0.05)。结论采用TMZ治疗能改善UA患者左室功能,提高治疗UA的效果。
Objective To investigate the effect of trimetazidine (TMZ) on left ventricular function in patients with unstable angina pectoris (UA) and its clinical efficacy, and to provide a theoretical basis for the clinical treatment of UA. Methods A total of 107 patients with unstable angina who were hospitalized from December 2005 to December 2010 were randomly divided into observation group (n = 53) and control group (n = 54). Control group received conventional anti-unstable angina drug therapy, including nitrates, β-blockers, calcium antagonists, anticoagulants, antiplatelet drugs, the observation group on the basis of conventional treatment with trimetazidine Zinc tablets 20mg / time, 3 times / d, a total of 12w. Cardiac function tests were performed with a color Doppler before and after treatment, and left ventricular end-diastolic diameter and end-systolic diameter (LVEDD, LVESD), left ventricular ejection fraction (LVEF), early diastolic and late diastolic blood flow were measured Ratio (E / A) and other parameters. Results After treatment, the total effective rate was 90.57% in the observation group and 75.93% in the control group. There was significant difference between the two groups (χ2 = 4.10, P <0.05). Compared with the control group, LVEDD, LVESD decreased and LVEF, E / A increased significantly in observation group (P <0.05). Conclusion TMZ treatment can improve left ventricular function in UA patients and improve the efficacy of UA.