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目的:评价分析血清胱抑素C与血清肌酐在重症监护病房(ICU)急性肾损伤(AKI)患者肾小球滤过率(GFR)评估中的临床价值,为今后的临床诊治工作提供可靠的理论依据。方法:抽取在2012年7月-2014年7月间我院ICU收治的急性肾损伤患者45例,以及同期健康体检者45例,对患者在入院后展开血清胱抑素C与血清肌酐水平检测,在肌酐值最大日进行血清胱抑素C水平检测,计算肌酐清除率与GFR。结果:肾损伤患者血清胱抑素C水平较健康组发生显著升高(P<0.05),AKI患者血清胱抑素C与GFR呈显著相关性。结论:ICU中可将血清胱抑素C作为急性肾损伤患者GFR理想标志物,且灵敏度较肌酐更高,值得关注。
OBJECTIVE: To evaluate the clinical value of serum cystatin C and serum creatinine in the assessment of glomerular filtration rate (GFR) in patients with intensive care unit (ICU) acute kidney injury (AKI), and to provide reliable data for future clinical diagnosis and treatment Theoretical basis. Methods: From July 2012 to July 2014, 45 patients with acute kidney injury admitted to our hospital and 45 healthy subjects were enrolled in this study. Serum levels of cystatin C and serum creatinine were measured after admission Serum cystatin C levels were measured at the maximum creatinine day, and creatinine clearance and GFR were calculated. Results: Serum levels of cystatin C in patients with renal injury were significantly higher than those in healthy controls (P <0.05). Serum levels of cystatin C were significantly correlated with GFR in patients with AKI. Conclusion: Serum Cystatin C can be used as an ideal marker of GFR in patients with acute kidney injury in ICU, and its sensitivity is higher than that of creatinine, which deserves attention.