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目的探讨乌司他丁对机械通气的急性肺损伤患者疗效。方法 45例机械通气治疗的急性肺损伤患者随机分为乌司他丁治疗组和对照组,治疗组予乌司他丁40万U每12 h一次,连用5 d,记录5 d内的各项指标。结果乌司他丁治疗组机械通气时间明显缩短,APACHEⅡ评分于用药后第3天明显降低,氧合指标明显好转,均有统计学差异。结论应用乌司他丁治疗可以促进机械通气的危重病患者呼吸功能的恢复。
Objective To investigate the effect of ulinastatin on patients with acute lung injury under mechanical ventilation. Methods Forty-five patients with acute lung injury treated with mechanical ventilation were randomly divided into ulinastatin group and control group. The treatment group received ulinastatin 400,000 U once every 12 hours for 5 days, recording the items within 5 days index. Results In the ulinastatin group, the duration of mechanical ventilation was significantly shortened. The APACHE Ⅱ score was significantly lower on the third day after administration and the oxygenation index was significantly improved, both of which were statistically different. Conclusion The application of ulinastatin can promote the resumption of respiratory function in critically ill patients with mechanical ventilation.