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目的了解老年肺部感染时机体细胞免疫状态,为合理有效的干预提供一定的参考。方法采用流式细胞仪检测老年肺部感染患者及健康老年组外周血淋巴细胞免疫表型(CD3,CD4,CD8,CD4/CD8比值,CD16,CD19),观察老年人肺部感染时机体细胞免疫功能变化。结果老年健康组CD3、CD4较对照组降低,CD4/CD8比值降低。老年感染组CD3、CD4、CD4/CD8比值、CD19较对照组及老年健康组均降低,CD8水平升高,差异均有统计学意义(P<0.05)。结论老年肺部感染的发生、发展与机体的细胞免疫功能紊乱有关。对细胞免疫功能的监测,可作为评估老年个体免疫状态及对老年肺部感染的预防、治疗以及合理有效干预的参考。
Objective To understand the status of somatic cell immunity in elderly patients with pulmonary infection and provide some reference for reasonable and effective intervention. Methods The peripheral blood lymphocyte immunophenotype (CD3, CD4, CD8, CD4 / CD8 ratio, CD16, CD19) in elderly patients with pulmonary infection and healthy elderly patients were detected by flow cytometry. Function changes. Results Elderly healthy group CD3, CD4 decreased compared with the control group, CD4 / CD8 ratio decreased. The ratio of CD3, CD4, CD4 / CD8 and CD19 in elderly infection group were lower than those in control group and elderly healthy group, CD8 level was increased, the difference was statistically significant (P <0.05). Conclusion The occurrence and development of elderly pulmonary infection are related to the cellular immune dysfunction. The monitoring of cellular immune function can be used as a reference to evaluate the immune status of elderly individuals and the prevention and treatment of senile pulmonary infection and reasonable and effective intervention.