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目的:调查本院宫颈疾病门诊高危型人乳头瘤病毒(HPV)感染基因亚型分布及年龄特点,为宫颈疾病病因提供参考依据。方法:用专用宫颈刷取妇女宫颈脱落细胞,利用基因芯片技术检测23种HPV亚型。结果:1521例患者中检出高危HPV阳性362例,占23.8%,感染率最高的亚型是16型,其他常见亚型依次为52、31、58。HPV感染的高峰年龄在18岁～30岁,而30岁以后HPV感染率明显下降,到40岁～49岁又一感染高峰。结论:HPV检测为一种较为方便、创伤小,敏感性高,是一种有效的宫颈病变的筛查方法。其感染HPV型别、年龄、感染持续时间决定病变的发展与预后。
Objective: To investigate the distribution and age characteristics of high risk human papillomavirus (HPV) in our clinic and provide a reference for the etiology of cervical diseases. Methods: Female cervical exfoliated cells were scrubbed with a special cervix, and 23 HPV subtypes were detected by gene chip technology. Results: A total of 362 high-risk HPV positive cases were detected in 1521 patients, accounting for 23.8%. The highest infection rate was 16 and the other common subtypes were 52, 31 and 58. The peak age of HPV infection is between 18 and 30 years old, but the HPV infection rate after 30 years of age obviously drops to the peak of 40 to 49 years old. Conclusion: HPV testing is a more convenient, less invasive, high sensitivity, is an effective screening method for cervical lesions. Its infection with HPV type, age, duration of infection determines the development and prognosis of the lesion.