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雌性成年大鼠切除胸腺后,其肝脏脂质过氧化产物丙二醛增多,还原型谷胱甘肽(GSH)含量减少,微粒体和线粒体膜流动性降低。隔日1次皮下注射自猪胸腺提取的胸腺因子D(TFD)2mg/kg共3月,可逆转去胸腺大鼠上述指标的变化。为了探讨胸腺影响肝脏抗氧化功能的中间途径,还测定了脾T淋巴细胞增殖反应及血浆性激素水平。结果表明,去胸腺大鼠脾脏T淋巴细胞增殖反应减弱、血浆雌二醇/睾酮比值下降;给予TFD可逆转其变化。实验结果提示,胸腺对大鼠肝脏抗氧化功能的影响可能与胸腺-内分泌-免疫网络有关。
After excision of thymus in female adult rats, hepatic lipid peroxidation products increased malondialdehyde, reduced glutathione (GSH) content and decreased fluidity of microsome and mitochondrial membrane. Subcutaneous injection of thymus factor 2 (TFD) 2mg / kg subcutaneously from pig thymus every other day for 3 months reversed the changes of the above indexes in thymus rats. In order to explore the thymus intermediate pathway of anti-oxidant function of the liver, spleen T-lymphocyte proliferation reaction and plasma hormone levels were also measured. The results showed that the proliferation of T lymphocytes in thymus rats decreased, and the ratio of plasma estradiol / testosterone decreased. The change of TFD could be reversed. The experimental results suggest that the thymus may play an important role in anti-oxidative function in rat liver, which may be related to thymus-endocrine-immune network.