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慢性阻塞性肺疾病(COPD)是呼吸系统常见的慢性非特异性炎症,目前认为有包括单核巨噬细胞在内的多种炎性细胞的参与。单核巨噬细胞能够分泌、调节多种炎性介质和蛋白,并和其他炎性细胞相互作用,形成一个复杂的炎性网络,使COPD患者肺组织中大量炎性细胞聚集、浸润,肺内损伤与修复交替出现,引起肺泡壁破坏和肺纤维化。单核巨噬细胞在COPD的发病过程中发挥关键的作用。
Chronic obstructive pulmonary disease (COPD) is a chronic nonspecific inflammation common to the respiratory system. Currently, it is thought that there are many inflammatory cells including mononuclear macrophages. Monocytes can secrete and regulate a variety of inflammatory mediators and proteins and interact with other inflammatory cells to form a complex inflammatory network that allows a large number of inflammatory cells to accumulate and infiltrate in the lung tissue of COPD patients, Damage and repair alternating, causing destruction of the alveolar wall and pulmonary fibrosis. Mononuclear macrophages play a key role in the pathogenesis of COPD.