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目的对亚临床甲状腺功能减退与冠心病的发生及发展的危险性的相关研究进行综述。方法查阅相关研究文献,分析并总结亚临床甲状腺功能减退加重冠心病危险性的相关性。结果亚临床甲状腺功能减退可以从多方面加速动脉粥样硬化的形成与发展,并可损害心脏的收缩、舒张功能,进而促进心血管事件的发生与发展,但此病理性改变过程是可逆性的。结论亚临床甲状腺功能减退在冠心病的发生与发展过程中起着重要的作用,但亚临床甲减是否是心血管事件的危险因素还有待进一步相关的临床研究来证明,以便更好地指导临床对其的预防、治疗与筛查。
Objective To summarize the related research about the subclinical hypothyroidism and the occurrence and development of coronary heart disease. Methods The related literatures were reviewed, and the correlation between subclinical hypothyroidism and coronary heart disease risk was analyzed and summarized. Results Subclinical hypothyroidism can accelerate the formation and development of atherosclerosis in many aspects, and can impair the cardiac systolic and diastolic function, thereby contributing to the occurrence and development of cardiovascular events, but the pathological changes are reversible . Conclusion Subclinical hypothyroidism plays an important role in the occurrence and development of coronary heart disease. Whether or not subclinical hypothyroidism is a risk factor for cardiovascular events remains to be confirmed by further relevant clinical studies in order to better guide clinical Its prevention, treatment and screening.