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麦门冬饮子(BI)由10种中药组成:沿阶草、人参、瓜蒌、知母、葛根、地黄、茯苓、五味子、甘草和淡竹叶。在东方传统医学中常用于治疗糖尿病。研究发现糖尿病小鼠口服BI后,能明显降低血糖。本次通过研究BI·对小肠中葡萄糖(glu)的吸收、α-葡糖苷酶的活性、Na~+-依赖型glu载体、GLUT5和SGLUT糖载体的影响,进一步探讨了BI降低血糖,治疗糖尿病的机理。 材料和方法:BI市售,成药1400mg溶解于20ml蒸馏水中,作为供试样品。选用雄性KK-Ay小鼠(12周龄),血糖高于16.653mmol/L。①小肠中glu的吸收。小
Maim Dong Yin Zi (BI) is composed of 10 kinds of Chinese medicines: Astragalus, Ginseng, Gualou, Anemarrhena, Pueraria, Rehmannia, Brassica, Schisandra, Radix Glycyrrhizae and Brassica. It is often used to treat diabetes in oriental traditional medicine. The study found that diabetic mice can significantly lower blood glucose after oral administration of BI. In this study, we investigated the effect of BI on the absorption of glucose (glu) in the small intestine, activity of α-glucosidase, Na+-dependent glu carrier, GLUT5, and SGLUT sugar carrier, and further explored that BI lowers blood sugar and treats diabetes. The mechanism. Materials and Methods: BI was commercially available, and 1400 mg of the drug was dissolved in 20 ml of distilled water as a test sample. Male KK-Ay mice (12 weeks old) were selected and the blood glucose was higher than 16.653 mmol/L. 1 absorption of glu in the small intestine. small