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以5-氨基水杨酸(5-ASA)为模型药物分子,pH敏感水凝胶聚甲基丙烯酸(PMAA)为载体,采用浸渍法实现了药物在载体上的负载,载药量约为23.3wt%。通过体外模拟释放实验,研究了该凝胶在不同pH值模拟胃液(pH=1.2)和模拟肠液(pH=7.5)中的释药行为。结果表明,药物在pH值较低的模拟胃液中释放的较慢,且最大累积释药率较低(～10.4%);在pH值较高的模拟肠液中释放的较快,最大累积释药率达～47.6%,并揭示了释药机理。因此,PMAA可实现药物5-ASA在模拟肠液中的靶向释放,在智能药物控释系统领域具有潜在的应用价值。
Using 5-aminosalicylic acid (5-ASA) as model drug and pH-sensitive hydrogel polymethacrylic acid (PMAA) as carrier, the drug loading on the carrier was achieved by impregnation. The drug loading was about 23.3 wt%. The release behavior of the gel in simulated gastric fluid (pH = 1.2) and simulated intestinal fluid (pH = 7.5) was studied by in vitro simulated release experiments. The results showed that the drug was released slowly in simulated gastric fluid with lower pH and the maximum cumulative release rate was lower (-10.4%); the faster and the largest cumulative release was in simulated intestinal fluid with higher pH Rate of ~ 47.6%, and revealed the mechanism of drug release. Therefore, PMAA can achieve targeted release of 5-ASA in simulated intestinal fluid and has potential application in the field of intelligent drug delivery system.