论文部分内容阅读
目的:探讨抑癌基因E钙黏蛋白(Ecad)在食管癌组织中的表达及其与临床病理特征和患者生存期的关系.方法:应用免疫组化SP法检测67例食管癌组织中Ecad的表达,并分析其与食管癌临床病理特征和淋巴结转移及患者生存期的关系.结果:食管癌组织中Ecad的表达水平明显高于正常组织(34/67vs6/31,P<0.01),异常表达率为50.8%;食管癌Ecad表达与食管癌的分化程度、浸润深度、淋巴结转移及患者的生存期密切相关(P均<0.05),而与患者的年龄、性别、肿瘤的大小、部位和形态无关(P>0.05).结论:Ecad异常表达与食管癌的发生发展密切相关,是判断食管癌侵袭转移及预后的一个重要指标.
Objective: To investigate the expression of Ecad in tumor tissue and its relationship with clinicopathological characteristics and patient survival.Methods: Immunohistochemical SP method was used to detect the expression of Ecad in 67 cases of esophageal carcinoma The expression of Ecad in esophageal squamous cell carcinoma and its relationship with clinicopathological features, lymph node metastasis and patient survival were analyzed.Results: The expression of Ecad in esophageal cancer tissues was significantly higher than that in normal tissues (34/67 vs 6/31, P <0.01) (50.8%). The expression of Ecad in esophageal cancer was closely related to the differentiation degree, depth of invasion, lymph node metastasis and survival of esophageal cancer (all P <0.05), but not with age, sex, tumor size, location and morphology (P> 0.05) .Conclusion: The abnormal expression of Ecad is closely related to the occurrence and development of esophageal cancer, which is an important index to judge the invasion, metastasis and prognosis of esophageal cancer.