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为探讨HBxAg在慢性肝炎、肝硬变和原发性肝癌病变发生中的意义,作者以ABC和PAP免疫组化法研究了HBxAg以及HBsAg和HBcAg在肝及肝癌组织内的存在与分布。在110例慢性肝炎中,72(65.5％)例显示HBxAg阳性,66(60%)例HBsAg和35(31.8%)例HBcAg阳性。在108例肝硬变中,84(77.8%)例显示HBxAg阳性,73(67.6％)例HBsAg和18(16.7％)例HBcAg阳性。在110例原发性肝癌病例中,64(58.2%)例在肝癌组织内显示HBxAg阳性,17(15.5%)例HBsAg和12(10.9%)例HBcAg阳性;在80例癌周肝组织内,63(78.8%)例显示HBxAg阳性,47(58.8％)例HBsAg和21(26.3％)例HBcAg阳性。上述结果表明,在慢性肝炎、肝硬变和肝癌内HBxAg的检出率比HBsAg和HBcAg高,在肝癌组织内尤为明显。本研究证明了慢性肝炎、肝硬变及原发性肝癌和HBV慢性感染有密切关系。
To explore the significance of HBxAg in the pathogenesis of chronic hepatitis, cirrhosis and primary liver cancer, the authors studied the presence and distribution of HBxAg, HBsAg and HBcAg in liver and liver cancer tissues by ABC and PAP immunohistochemistry. Among 110 chronic hepatitis cases, 72 (65.5%) showed HBxAg positive, 66 (60%) HBsAg and 35 (31.8%) HBcAg positive. Of 108 cirrhotic cases, 84 (77.8%) showed HBxAg positive, 73 (67.6%) HBsAg and 18 (16.7%) HBcAg positive. Among the 110 cases of primary liver cancer, 64 (58.2%) showed HBxAg positive in HCC, 17 (15.5%) HBsAg and 12 (10.9%) HBcAg positive. In 80 cases of peritumoral liver tissue, 63 (78.8%) cases showed HBxAg positive, 47 (58.8%) HBsAg and 21 (26.3%) HBcAg positive. The above results show that the detection rate of HBxAg in chronic hepatitis, cirrhosis and liver cancer is higher than that of HBsAg and HBcAg, especially in liver cancer. This study demonstrates that chronic hepatitis, cirrhosis and primary liver cancer are closely related to chronic HBV infection.