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由于亚硝脲衍生物(ACNU)能通过血脑屏障(BBB),故广泛应用于脑肿瘤治疗。但由于此类衍生物有抗药性,已成为治疗中的障碍。作者发现利血平可增强ACNU对抗ACNU胶质细胞的细胞毒性,并进一步通过对C_6胶质瘤细胞(C_6)及其亚系抗ACNU胶质瘤细胞(C_6/ACNU)的体外和体内试验证实了利血平的作用。体外试验ACNU对体外培养的C_6和C_6/ACNU细胞50%抑制生长所需药物浓度(IC_(50))分别为26.8和38.8μM。如培养液中加入10μM的利血平,
Since nitrosourea derivatives (ACNU) can pass through the blood-brain barrier (BBB), they are widely used in the treatment of brain tumors. However, due to the resistance of such derivatives, it has become an obstacle in the treatment. The authors found that reserpine enhances the cytotoxicity of ACNU against ACNU glial cells, and further confirmed by in vitro and in vivo tests on C_6 glioma cells (C_6) and its subline anti-ACNU glioma cells (C_6/ACNU). The role of reserpine. The concentration of drug (IC_(50)) required for 50% inhibition of growth of C_6 and C_6/ACNU cells cultured in vitro by ACNU in vitro was 26.8 and 38.8 μM, respectively. If 10 μM reserpine is added to the culture fluid,