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目的 :明胶-聚苯胺接枝共聚物(gelatin-graft-polyaniline,GP)导电水凝胶的制备和性能研究。方法:采用直接掺杂法制作GP,使用樟脑磺酸(camphor sulfonic acid,CSA)作为掺杂剂。GP溶于水形成导电水凝胶(gelatin-graft-polyaniline hydrogel,GPH),以1-(3-二甲氨基丙基)-3-乙基碳二亚胺盐酸盐[1-(3-dimethylaminoproply)-3-ethylcarbodiimide,EDC]进行交联。对制备的GP和GPH的形态结构、生物相容性、溶解性、溶胀比和导电性能进行观察研究。结果:GPH导电性能良好(1×10~(-4)~1×10~(-3)S/cm),并随着苯胺含量的增大而增大。但当苯胺的量提高到一定程度,通过明胶共聚获得的GPH溶解性大大降低,同时溶胀比增加。结论:GPH是一种新型的可降解生物材料,具有良好的导电性能,作为支架在组织工程修复中有巨大的应用前景。
Objective: To study the preparation and properties of gelatin-graft-polyaniline (GP) conductive hydrogels. Methods: GP was prepared by direct doping method using camphor sulfonic acid (CSA) as dopant. GP was dissolved in water to form a gelatin-graft-polyaniline hydrogel (GPH), and 1- (3- dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride [1- dimethylaminoproply) -3-ethylcarbodiimide, EDC]. The morphological structure, biocompatibility, solubility, swelling ratio and electrical conductivity of prepared GP and GPH were observed and studied. Results: The conductivity of GPH was good (1 × 10 -4 ~ 1 × 10 -3 S / cm) and increased with the increase of aniline content. However, when the amount of aniline is increased to a certain extent, the solubility of GPH obtained by gelatin copolymerization is greatly reduced while the swelling ratio is increased. Conclusion: GPH is a new type of biodegradable biomaterial with good conductivity. As a scaffold, GPH has great potential applications in tissue engineering.