本文研究急性运动后糖皮质激素(GC)分泌增多对大鼠心、肾细胞糖皮质激素受体(GR)及Na~+-K~+-ATP 酶的影响,结果表明,无负荷游泳后造成 GR 的适度减少,伴有对 Na~+-K~+-ATP 酶的诱导加强,其发生可分别被 Trilostane 和 RU_(A86)抑制;6%体重负荷游泳1h 后,出现 GR 过度减少并伴有血浆 GC 对靶细胞 Na~+-K~+-ATP 酶诱导抑制,提示靶细胞对 GC 抵抗。本文提出运动时 GR 过度下降是限制机体运动能力的一个重要因素。 This article studies the effect of increased secretion of glucocorticoid (GC) on glucocorticoid receptor (GR) and Na ~ + -K ~ + -ATPase in rat heart and kidney after acute exercise. The results show that after exercise, The moderate decrease of GR accompanied with the induction of Na ~ + -K ~ + -ATPase was inhibited by Trilostane and RU_ (A86) respectively. After 1 hour of 6% body weight swimming, the excessive decrease of GR accompanied with Plasma GC induced target Na ~ + -K ~ + -ATP enzyme inhibition, suggesting that target cells against GC. In this paper, we propose that excessive decrease of GR during exercise is an important factor that limits the exercise capacity of the body.