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目的 对我院16例胃肠道恶性淋巴瘤(PGIL)临床资料进行分析,以提高对该病的认识。方法 收集1999年6月—2004年2月在我院住院16例病例,对其临床表现、诊断治疗及预后等进行总结分析。结果 16例均为经病理、免疫组化等检查确诊的胃肠道恶性淋巴瘤。其中胃非霍奇金氏淋巴瘤(NHL)9例、肠 NHL7 例(十二指肠2例、小肠2例、回盲部2例、大肠1例),临床分期ⅠE1例、Ⅱ1E3例、Ⅱ2E5例、ⅢE6例、ⅣE1例,病理类型16例均系非霍奇金氏淋巴瘤,其中弥漫性大B细胞型8例,2例为T细胞型淋巴瘤,B细胞性小淋巴细胞型、滤泡小裂细胞性及淋巴浆细胞性各2例。16例均行手术治疗,术后辅以联合化疗,方案为COP或CHOP。随访率56.2%,9例可随访,4例失随访,3例死亡。结论 本病误诊率较高,手术切除是 PGIL的首选疗法,术后辅以化(放)疗及综合性治疗措施,可以提高患者生存期。
Objective To analyze the clinical data of 16 cases of gastrointestinal malignant lymphoma (PGIL) in our hospital to improve the understanding of the disease. Methods Totally 16 cases hospitalized in our hospital from June 1999 to February 2004 were collected, and their clinical manifestations, diagnosis, treatment and prognosis were analyzed. Results All the 16 cases were diagnosed as gastrointestinal malignant lymphoma by pathology and immunohistochemistry. There were 9 cases of non-Hodgkin lymphoma (NHL), 7 cases of NHL (2 cases of duodenum, 2 cases of small intestine, 2 cases of ileocecal region and 1 case of large intestine), clinical stage ⅠE1, Ⅱ1E3, Ⅱ2E5 Cases, Ⅲ E6 cases, Ⅳ E1 cases, pathological type 16 cases were non-Hodgkin’s lymphoma, diffuse large B cell type in 8 cases, 2 cases of T cell lymphoma, B cell lymphoblastoid type, filter Small pericytes and lymphoplasmacytic cells in 2 cases. Sixteen patients underwent surgery, postoperative combined with chemotherapy, the program for the COP or CHOP. Follow-up rate was 56.2%, 9 cases were followed up, 4 cases lost follow-up and 3 cases died. Conclusion The higher misdiagnosis rate of the disease, surgical resection is the preferred treatment of PGIL, postoperative adjuvant (radiotherapy) and comprehensive treatment measures, can improve the survival of patients.