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近几年来,利用某些制剂非特异性地刺激机体的免疫系统作为治疗肿瘤的免疫学疗法越来越受到人们的重视。许多学者研究发现,某些细菌本身及其产物如卡介苗(BCG)、短小棒状杆菌(C.parvum)、细菌的脂多糖(LPS)等,可以激活体内的巨噬细胞(MΦ)而分泌多种生物活性物质,其中有些物质如精氨酸酶(Arginase)、C_3裂解产物(C_(3a))中性蛋白酶及过氧化物酶等,均能非特异性地杀伤多种肿瘤细胞。Carswell等(1975)在研究由内毒素引起的肿瘤“出血性”坏死现象时发现,经BCG-LPS处理后的CD-Swiss小鼠血清中存在一种细胞毒因子,它可以导致经皮下移植的Meth A肉瘤的“出血性”坏死作用,对体外培养的某些瘤细胞或经病毒转化的细胞也具有细胞毒作用,但对机体的正常细胞如鼠胚
In recent years, the use of certain agents to non-specifically stimulate the body’s immune system as an immunotherapy for the treatment of tumors is gaining more and more attention. Many scholars have found that some bacteria themselves and their products such as BCG, C.parvum, LPS and so on can activate macrophages (MΦ) in vivo to secrete a variety of Bioactive substances, some of which substances such as arginase (Arginase), C_3 cleavage products (C_ (3a)) neutral protease and peroxidase, can all kinds of non-specific killing of tumor cells. In a study of the “hemorrhagic” necrosis of tumors caused by endotoxin, Carswell et al. (1975) found that the presence of a cytotoxic agent in the serum of CD-Swiss mice treated with BCG-LPS results in subcutaneous transplanted The “hemorrhagic” necrosis of Meth A sarcoma also has cytotoxic effects on some tumor cells or virus-transformed cells cultured in vitro, but also on the normal cells of the body such as the mouse embryos