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目的:评价中医膳食食疗联合TP(紫杉醇+顺铂)方案化疗治疗晚期卵巢癌的临床疗效。方法:将86例晚期卵巢癌患者随机分为单纯化疗组和中医膳食食疗加化疗组。单纯化疗组患者用TP方案化疗,单独使用化疗药物,化疗结束后不再用药;中医膳食食疗加化疗组在该方案化疗基础上于化疗第2天给予参芪健脾汤中医膳食食疗,至下一周期化疗开始。比较患者治疗后1,2年的生活质量及随访3年的死亡及转移情况,并检测外周血T淋巴细胞亚群、自然杀伤(NK)细胞等免疫指标。结果:中医膳食食疗加化疗组治疗1年后的生活质量明显高于单纯化疗组,呈显著性差异(P<0.05);2年后的生活质量与单纯化疗组比较无显著性差异;3年后的病死率和转移率明显低于对照组,与单纯化疗组比较,呈显著性差异(P<0.05)。中医膳食食疗加化疗组治疗后,CD4+明显升高,CD8+明显降低,CD4+/CD8+明显升高,NK细胞活性明显提高,与单纯化疗组治疗后比较,均呈非常显著性差异(P<0.05)。结论:中医膳食食疗联合化疗治疗晚期卵巢癌患者能提高患者外周血中免疫细胞的活性,增强免疫力,可提高患者的生活质量,延长寿命,降低病死率和远处转移率,临床效果确切,患者耐受性好,值得临床推广。
Objective: To evaluate the clinical efficacy of traditional Chinese medicine diet combined with TP (paclitaxel + cisplatin) chemotherapy in the treatment of advanced ovarian cancer. Methods: Eighty-six patients with advanced ovarian cancer were randomly divided into chemotherapy group and TCM diet plus chemotherapy group. Patients in the simple chemotherapy group were treated with TP regimen and chemotherapy alone, and were no longer treated with chemotherapy after the chemotherapy was over. On the basis of this regimen and chemotherapy regimen, Chinese medicine diet plus chemotherapy group was given Shenqi Jianpi Decoction traditional Chinese medicine diet therapy on the basis of this regimen, One cycle of chemotherapy begins. The quality of life at 1 and 2 years after treatment and the death and metastasis of the patients after 3 years of follow-up were compared. The immune indexes such as peripheral blood T lymphocyte subsets and natural killer (NK) cells were also detected. Results: The quality of life of Chinese medicine diet plus chemotherapy group after 1 year was significantly higher than that of chemotherapy alone group (P <0.05); after 2 years, the quality of life was not significantly different from that of chemotherapy alone group; 3 years After the mortality and metastasis rate was significantly lower than the control group, compared with the chemotherapy alone group, a significant difference (P <0.05). The levels of CD4 +, CD8 +, CD4 + / CD8 + and NK cell activity in the treatment group were significantly higher than those in the chemotherapy group (P <0.05) . Conclusion: The combination of TCM dietotherapy and chemotherapy in patients with advanced ovarian cancer can improve the immune cell activity in the peripheral blood of patients and enhance the immunity, which can improve the quality of life of patients, prolong the life span, reduce the mortality and distant metastasis rate. The clinical effect is exact, Patients are well tolerated, it is worth clinical promotion.