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子痫前期是一种严重影响母婴健康的疾病,确切发病机制至今不明,遗传易感因素在其发病中发挥了举足轻重的作用,凝血与纤溶异常、胎盘发育障碍、氧化应激、脂质代谢异常及炎症因子等相关基因的多态性均与子痫前期的发病密切相关;印迹基因在子痫前期的发病中也发挥着重要作用。明确子痫前期的遗传发病机制,可为疾病的预测、预防、治疗提供新的方向和思路。
Pre-eclampsia is a serious disease affecting maternal and infant health. The exact pathogenesis remains unclear. Genetic predisposition plays a pivotal role in its pathogenesis. Coagulation and fibrinolytic disorders, placental developmental disorders, oxidative stress, lipid Metabolic abnormalities and inflammatory cytokines and other related gene polymorphisms are closely related with the pathogenesis of preeclampsia; imprinted genes also play an important role in the pathogenesis of preeclampsia. To clarify the genetic pathogenesis of preeclampsia can provide new directions and ideas for the prediction, prevention and treatment of diseases.