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目的 :观察醋氨己酸锌对肝硬化合并消化性溃疡的疗效。方法 :肝硬化合并十二指肠溃疡 36例和合并胃溃疡 30例 ,随机分为醋氨己酸锌组 (醋氨己锌 0 .3g ,po ,tid ,其中胃溃疡 12例、十二指肠溃疡 12例 )、法莫替丁组 (法莫替丁 2 0mg ,po ,bid ,其中胃溃汤 9例、十二指肠溃疡 10例 )、联合用药组 (醋氨己酸锌 0 .3g ,po ,tid ,法莫替丁 2 0mg ,po ,bid ,其中胃溃疡 9例、十二指肠溃疡 14例 ) ,共3组。治疗胃溃疡疗程 6wk ,十二指肠溃疡疗程为4wk ,疗程结束后 ,用内窥镜观察溃疡愈合情况。结果 :醋氨己酸锌组肝硬化合并胃溃疡和十二肠溃疡的愈合率分别为 5 8% ,6 6 % ,法莫替丁组分别为5 6 % ,70 % ,联合用药组分别为 78% ,79% ,3组比较差异无显著意义 ,P >0 .0 5。结论 :醋氨己酸锌治疗肝硬化合并消化性溃疡的疗效与其他 2组相似 ,但其安全性好
Objective: To observe the curative effect of zinc acetohexaminate on patients with cirrhosis and peptic ulcer. Methods: Thirty-six patients with liver cirrhosis complicated with duodenal ulcer and 30 patients with gastric ulcer were randomly divided into three groups: zinc acetohexanoate (Acetaminophen 0.3g, po, tid, gastric ulcer 12, Intestinal ulcer in 12 cases), famotidine group (famotidine 20mg, po, bid, including gastric ulcer in 9 cases, duodenal ulcer in 10 cases) 3g, po, tid, famotidine 20mg, po, bid, of which 9 cases of gastric ulcer, duodenal ulcer in 14 cases), a total of 3 groups. Treatment of gastric ulcer course 6wk, duodenal ulcer course of treatment 4wk, after the end of treatment, ulcer healing observed with endoscopy. Results: The healing rates of liver cirrhosis with gastric ulcer and duodenal ulcer in zinc acetohexamide group were respectively 58% and 66%, respectively, while those in famotidine group were respectively 56% and 70% 78% and 79% respectively. There was no significant difference between the three groups (P> 0.05). Conclusion: The curative effect of zinc acetimide on cirrhosis complicated with peptic ulcer is similar to other two groups, but its safety is good