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应用LSAB免疫组化方法研究P53和nm23表达变化与胃癌生物学行为及淋巴结转移和预后的关系。发现P53及nm23的阳性率分别为61%、60%。P53过表达与淋巴结转移和预后关系密切(P<001)。nm23低表达与胃癌侵袭程度、淋巴结转移及预后有明显关系(P<001)。P53过表达和nm23低表达在胃癌淋巴结转移及预后中可能起协同作用。提示检测P53蛋白及nm23基因表达状况可作为临床预测胃癌淋巴结转移及预后的一项指标。
LSAB immunohistochemistry was used to study the relationship between the expression of P53 and nm23 and the biological behavior, lymph node metastasis and prognosis of gastric cancer. The positive rates of P53 and nm23 were found to be 61% and 60%, respectively. P53 overexpression was closely related to lymph node metastasis and prognosis (P < 001). The low expression of nm23 was significantly associated with the degree of invasion, lymph node metastasis and prognosis of gastric cancer (P < 001). Overexpression of P53 and low expression of nm23 may play a synergistic role in lymph node metastasis and prognosis of gastric cancer. The detection of P53 protein and nm23 gene expression status can be used as a clinical indicator of lymph node metastasis and prognosis of gastric cancer.