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目的：分析医院2014－2015年无菌体液中凝固酶阴性葡萄球菌（ CNS）的分布及耐药性，指导临床合理使用抗生素。方法采用回顾性方法分析医院2014年1月－2015年12月无菌体液中分离出的CNS分布及耐药性。结果150株CNS中，耐青霉素CNS菌株占100．0％；耐甲氧西林的CNS菌株（ MRCNS）102株，占68．0％。检出4株对万古霉素中介耐药的CNS菌株，不同科室CNS感染的检出率：ICU占35．3％、儿科占24．0％；102株MRCNS菌株中，46株分离自ICU患者的MRCNS菌株对多数抗菌药物的耐药率在50．0％以上，分析出4株对万古霉素中介的菌株。结论 CNS多重耐药现象严重，ICU患者应加强MRCNS菌株的检测及药物敏感性的监测，治疗CNS感染应合理使用万古霉素。“,”Objective To analysis drug sensitivityof coagulase negative staphylococcus(CNS) in a hospital which guides clinical doctors using antibioticcsrationally.Methods Identified and do drug sensitive test to 150 strains of CNS in a hospital from 2014-2015 with the VITEK 2-Compact Bacteria Identification and Drug susceptibility.150 strains of CNS,resist-ant to penicillin CNS strains accounted for 100.0%,methicillin-resistant CNS strains ( MRCNS) accounted for 68.0%,We detected that 4 strains resistant to vancomycin intermediary of CNS strains;CNS drug sensitivity detection rate from different departments:ICU accounted for 35.3%and Pediatric accounted for 24.0%;102 strains of MRCNS,46 strains of MRCNS that isolated from ICU patients resistant to most antimicrobial resistant accounted over 50.0%;There was statistically significant difference that MRCNS resistant to gentamicin,clindamycin and ciprofloxacin between isolated from ICU patients and not isola-ted from ICU patients.Conclusion CNS multiple drug resistance is serious,ICU patients should strengthen the detection of MRCNS strains and the supervision of drug sensitivity;Treatment of CNS infection should use vancomycin rationally.