全世界气道变态反应性疾病发病率高达10%~25%,是一个影响全球的健康问题,其在临床上主要包括变应性鼻炎和哮喘。变应性鼻炎与哮喘的发生发展关系密切,变应性鼻炎常为哮喘的先兆,是哮喘的危险因素[1]。尽管目前临床治疗有了长足的进展,但远期效果并不理想,因此努力寻找治疗气道变态反应性疾病的新靶位迫在眉睫。近年来的研 The global incidence of allergic airway disease as high as 10% to 25%, is a global health problems, which clinically include allergic rhinitis and asthma. Allergic rhinitis is closely related to the occurrence and development of asthma. Allergic rhinitis is often a harbinger of asthma and a risk factor for asthma [1]. Despite the great progress made in clinical treatment at present, the long-term effect is not satisfactory. Therefore, it is imperative to find a new target for the treatment of airway allergic diseases. Research in recent years