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在食管癌的病因研究中,亚硝胺的作用日益受到高度重视,用高发区浓缩10倍的井水给实验动物作腹腔注射,在107天内实验动物前胃发生了癌前病变。经气相色谱测定证实高发区的一些井水中含有二乙基亚硝胺。以此水样诱癌,185天时实验鼠发生了增生和癌前病变(2)。因此、探讨亚硝胺诱癌规律,为人类食管癌的病因,发病研究提供丰富的实验资料是很必要的。文献中有关癌变的研究,大都采用组织病理学方法(3～5)本研究使用透射电镜和扫描电镜的方法,着重对三种亚硝胺诱发的小鼠食管癌前病变的超微结构作综合观察,并对有关问题进行讨论。
In the etiology of esophageal cancer, the role of nitrosamines has been paid more and more attention. With high-concentrated areas of 10 times the well water to the experimental animals for intraperitoneal injection, in 107 days before the experimental animal precancerous lesions. Gas chromatography confirmed that some well water in high incidence areas contained diethylnitrosamine. As a water-induced cancer, 185 days when the mice developed hyperplasia and precancerous lesions (2). Therefore, it is necessary to explore the rule of carcinogenesis of nitrosamines and provide abundant experimental data for the study of the etiology and pathogenesis of human esophageal cancer. In the literature about carcinogenesis, mostly using histopathological methods (3 ~ 5) in this study using transmission electron microscopy and scanning electron microscopy methods, focusing on the three kinds of nitrosamine induced esophageal precancerous lesions in mice made a comprehensive Observe and discuss the relevant issues.