本文作者研究了3例致死性高热综合征患者(临床诊断为致死性紧张症和恶性症状群)尸体脑内DA、NE和Ach系统的情况。例1 16岁,例2 24岁,例3 54岁。结果发现,例1、2病人迈内特氏底核中的大神经元的细胞体明显消失,一些神经细胞的核固缩,神经纤维网中有海绵状改变。但没有发现大脑皮质和海马有老年斑和神经原纤维缠结。例3的基底核在正常范围,小脑切片发现部分浦肯野氏细胞硬化,其他细胞排列紊乱、核固缩、嗜伊红深染。但例1、2小脑组织学分析未发现异常。为了排除年龄对神经递质水平的影响,对照组按年龄配 The authors studied the DA, NE, and Ach systems in the cadaver brain of three patients with lethal Hyperthermia (clinically diagnosed as lethal and malignant). Example 1 16 years old, case 2 24 years old, case 3 54 years old. The results showed that in Example 1 and 2 patients, the cell bodies of the large neurons in the Manetre’s nucleus significantly disappeared. Some nerve cells were nuclear pyknotic with a spongy change in the nerve fiber network. However, no cerebral plaques and hippocampus senile plaques and neurofibrillary tangles were found. Example 3 of the basal ganglia in the normal range, cerebellar sections found Purkinje cells sclerosis, other cells arranged disorder, nuclear pyknosis, eosin staining. However, cases 1, 2 cerebellar histological analysis found no abnormalities. To exclude the effect of age on neurotransmitter levels, the control group was age-matched