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目的分析麻疹疫苗接种后抗体滴度水平与年龄的关系,为麻疹疫苗接种提供依据。方法以沾化县8个月龄~20岁的健康人群为观察对象,分年度、分年龄组进行麻疹抗体检测。抗体测定采用血凝抑制试验。用等级相关、等级秩和检验及x2检验的统计学方法进行评价。结果不同年份抗体滴度水平不相关,中位数等级相关(R s=0.5,P>0.05),秩和检验(Hc=705.49,P<0.05),x2检验(x2=554.33,P<0.05);不同年龄组抗体滴度水平不同,中位数等级相关(R s=-0.884,P<0.05),秩和检验(Hc=-476.55,P<0.05),x2检验(x2=98.38,P<0.05)。结论麻疹疫苗接种后抗体的高水平只能维持2~3年,在大年龄组儿童及成人中应进行麻疹接种。
Objective To analyze the relationship between antibody titers and age after measles vaccination, and provide evidence for measles vaccination. Methods The healthy population from 8 months to 20 years old in Zhanhua County was taken as the observation object, and the measles antibody was tested in the year and the age group. Antibody assay using hemagglutination inhibition test. The rank correlation, rank rank test and x2 test were used for statistical evaluation. Results There was no correlation between antibody titers in different years and the median (Rs = 0.5, P> 0.05), rank sum test (Hc = 705.49, P < (R s = -0.884, P <0.05), rank sum test (Hc = -476.55, P <0.05), x2 test (x2 = 98.38, P < 0.05). Conclusion The high level of antibody after measles vaccination can only last 2-3 years. Measles vaccination should be carried out in children and adults in large age group.