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目的总结2002年10月-2007年9月期间衢州市先天性甲状腺功能低下症(CH)的筛查结果及体会。方法统一送至浙江省新生儿疾病筛查中心化验。采用时间分辨荧光免疫法检测滤纸血斑中TSH值;采用化学发光免疫分析法检测血清中TSH、T4、T3水平。结果①2002年-2007年共筛查新生儿128273例,全市覆盖率为87.0%。②6年共检出CH136例,发病率为1/943。结论①我市CH发病率远远高于全国的发病率,在全省也属于高发地区。可能与缺碘和经济发展之滞后有关。②我省统一在省新生儿疾病筛查中心进行CH及PKU的筛查,这是一个较好的模式。
Objective To summarize the screening results and experiences of congenital hypothyroidism (CH) in Quzhou from October 2002 to September 2007. Methods unified sent to Zhejiang Province neonatal disease screening center test. The time-resolved fluorescence immunoassay was used to detect the TSH value in the filter paper blood spots. The levels of TSH, T4 and T3 in serum were detected by chemiluminescence immunoassay. Results ① From 2002 to 2007, a total of 128,273 newborns were screened, covering 87.0% of the whole city. ② 6 years were detected in CH136 cases, the incidence was 1/943. Conclusions ① The incidence of CH in our city is much higher than that of the whole country, and it is also a high incidence area in the whole province. It may be related to iodine deficiency and the lag of economic development. ② our province unified screening of CH and PKU at the Provincial Newborn Disease Screening Center, which is a better model.