叶酸的拮抗药甲氨喋呤(Methotrexate,MTX)早在1948年已开始用于肿瘤的治疗,并随着用量及使用方法的改进,临床疗效不断有所提高。目前已成为治疗白血病、绒毛膜上皮癌、肺癌、乳癌以及恶性淋巴瘤的常用药。特别是七十年代初始,国外盛行大剂量MTX治疗,用量较目前我国常用量大数倍至数十倍,然后再用MTX的拮抗药甲酰四氢 Folic acid antagonist Methotrexate (MTX) as early as 1948 has been used for the treatment of tumors, and with the amount and use of improved methods, clinical efficacy has been continuously improved. Has now become the treatment of leukemia, choriocarcinoma, lung cancer, breast cancer and malignant lymphoma commonly used drugs. Especially the beginning of the seventies, the prevalence of large doses of MTX treatment abroad, the amount used in China than the current number of times several times to several times, and then use MTX antagonist formyl tetrahydro