The dynamical process in the superheavy nucleus synthesis is studied on the basis of the two-dimensional Smolu-chowski equation. Special attention is paid to the isotope dependence of the cross section for the superheavy nucleus formation by means of making a comparison among the reaction systems of 54Fe + 204Pb, 56Fe + 206Pb, and 58Fe + 208Pb. It is found by this comparison that the formation cross section is very sensitive to the conditional saddle-point height and the neutron separation energy of the compound nucleus. Reaction systems with lower height of conditional saddle-point and smaller neutron separation energy are more favourable for the synthesis of the superheavy nucleus.