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本文报导了~(131)I-利儿诺在86只中期妊娠小鼠体内的吸收、分布和清除规律。实验表明(1):羊膜腔内注入的~(131)I-利凡诺能迅速进入母体,但主要脏器中含量在4小时达吸收高峰时只占投入量的3.53%,脏器中放射性百分含量按肝>胃>肺>脾>心>甲状腺、脑之顺序而递减。血中放射性百分含量很低。(2)药物主要经注药侧的胎鼠吞入和吸入后通过胎盘血流进入母体,并再随未注药侧的胎盘血进入其它胎鼠,未明显见到有局部扩散或渗透现象。(3)母体对药物的清除以消化系统胆、胃和肾脏为主。用药后3天约有一半放射性由母体粪尿中排出,粪排大于尿排。
This paper reports the absorption, distribution and clearance of ~ (131) I-leptin in 86 pregnant mice. Experiments show that (1): ~ (131) I-rivanol into the amniotic cavity can quickly enter the mother, but the main organs in the content reached 4 hours up to the absorption peak of only 3.53% of the input, organ radioactivity Percentage decreased by the order of liver> stomach> lung> spleen> heart> thyroid, brain. The radioactive content in the blood is low. (2) The drug mainly enters the mother through the placental blood flow after inhalation and inhalation, and then enters the other fetus with the uninjected side placental blood, and it is not obvious that there is any local diffusion or infiltration. (3) The mother of the drug to clear the digestive system gall bladder, stomach and kidney-based. About half of the radioactivity is excreted in maternal urine 3 days after administration, and fecal discharge is greater than that of urine.