脑血管病已成为危害中老年人身体健康及生命的主要疾病,其中缺血性脑卒中占脑血管病的比例>70%[1],进展性脑卒中是急性缺血性脑卒中的一种特殊类型,一直是备受关注的临床问题。以往常将单发性皮质下小梗死(Single Small Subcortical Infarctions,SSSI)与腔隙性脑梗死混为一谈,后者被认为是由小动脉病变所致,主要以纤维蛋白样降解或脂质透明变性为病理特征,神经功能缺损相对受限[2];更多研究表明SSSI的病理机制还包括载体动脉粥样硬化性病变闭塞穿支动脉,其早期神经功能恶化(Early Neurologi- Cerebrovascular disease has become a major disease endangering the health and life of the elderly, including ischemic stroke accounted for more than 70% of cerebrovascular disease [1], progressive stroke is a kind of acute ischemic stroke Special types have always been the subject of much-anticipated clinical problems. In the past, Single Small Subcortical Infarctions (SSSI) were often confused with lacunar infarctions, which are believed to be caused by arteriolar lesions, mainly fibrin-induced degradation or lipid degeneration Pathological features, neurological deficits are relatively limited [2]; more studies have shown that pathological mechanisms of SSSI include atherosclerosis of the carrier occlusion perforation of the artery, its early neurological deterioration (Early Neurologi-