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目的探讨软组织间叶性软骨肉瘤的临床病理学特征及诊断、鉴别诊断要点。方法对2例软组织发生的间叶性软骨肉瘤的组织学形态,免疫组化结果进行分析,并复习相关文献。结果肿瘤由两种成分组成,一种为圆形或短梭形未分化样小细胞成分,围绕血管排列呈血管外皮瘤样,另一种为高分化的软骨小岛成分,局部见钙化。免疫组化结果未分化小细胞呈现CD99、NSE阳性,软骨灶呈S-100蛋白阳性。结论软组织间叶性软骨肉瘤是一种少见的高度恶性肿瘤,诊断主要依靠光镜下见到未分化小细胞及分化较成熟的软骨两种病灶同时存在,免疫组化染色对诊断有一定帮助。
Objective To investigate the clinicopathological features and diagnosis and differential diagnosis of soft tissue mesenchymal sarcoma. Methods Tissue morphology and immunohistochemistry results of 2 cases of mesenchymal chondrosarcoma in soft tissue were analyzed and related literatures were reviewed. Results The tumor consisted of two components, one is a small round cell or short spindle undifferentiated small cell component, arranged around the blood vessel vascular hemangioid sample, the other is a highly differentiated cartilage island component, see the local calcification. Immunohistochemical results of undifferentiated small cells showed CD99, NSE positive, cartilage lesions were S-100 protein positive. Conclusions Soft tissue mesenchymal sarcoma is a rare high grade malignant tumor. The diagnosis mainly depends on the presence of undifferentiated small cells and differentiated mature cartilage in the light microscope. Immunohistochemical staining may be helpful in the diagnosis.