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6β-乙酰氧基去甲莨菪烷(6β-acetoxynortropane,6β-AN)是人工合成的新型拟胆碱莨菪烷类化合物,对心率和血压有抑制作用。6β-AN使心率减慢和血压降低的程度与剂量成正比关系。心率减慢和血压降低之间不论用或不用阿托品两者都密切相关。不同剂量阿托品使6β-AN的剂量-效应曲线都平行右移。阿托品的竞争性拮抗效应在心率和血压以拮抗指数表示。分别为5.65和5.66。
6β-Acetoxynortropane (6β-AN) is a synthetic novel choline tropane, which has an inhibitory effect on heart rate and blood pressure. 6β-AN slows down the heart rate and blood pressure is proportional to the degree and dose. Both the slowing of heart rate and the lowering of blood pressure are closely related with or without atropine. Different dose of atropine 6β-AN dose-response curve parallel to the right shift. Competitive antagonistic effects of atropine in the heart rate and blood pressure to antagonistic index. 5.65 and 5.66 respectively.