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目的探讨白细胞介素-4(IL-4)、白细胞介素-17(IL-17)、γ干扰素诱导蛋白-10(IP-10)、免疫球蛋白E(IgE)在毛细支气管炎患儿外周血中的水平变化及意义。方法选择2014年9月-2016年9月在该院接受治疗的100例毛细支气管炎患儿为观察组,按病情程度分作轻度组(48例)和重度组(52例),选择同期门诊健康体检婴幼儿100例为对照组。观察各组患儿外周血IL-4、IL-17、IP-10、IgE的水平。结果观察组患儿外周血IL-4、IL-17、IP-10、IgE高于对照组(P<0.05),重度组患儿外周血IL-4、IL-17、IP-10、IgE高于轻度组(P<0.05)。结论观察组患儿外周血IL-4、IL-17、IP-10、Ig E含量能够辅助疾病的诊断,进一步指导临床治疗。
Objective To investigate the effects of interleukin-4 (IL-4), interleukin-17 (IL-17), interferon-inducible protein-10 (IP-10) and IgE in children with bronchiolitis Peripheral blood levels change and its significance. Methods A total of 100 children with bronchiolitis treated in our hospital from September 2014 to September 2016 were selected as the observation group and 48 cases in the mild group and 52 cases in the severe group according to the severity of illness. Outpatient health examination 100 cases of infants and young children as a control group. The levels of IL-4, IL-17, IP-10 and IgE in the peripheral blood in each group were observed. Results The levels of IL-4, IL-17, IP-10 and IgE in the peripheral blood of the observation group were significantly higher than those of the control group (P <0.05) In mild group (P <0.05). Conclusion The levels of IL-4, IL-17, IP-10 and IgE in the peripheral blood of the observation group can help to diagnose the disease and further guide the clinical treatment.