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系统性硬化病 (ＳＳｃ)是一种结缔组织的多系统紊乱 ,临床上以皮肤纤维化、内脏器官受累及相当高的发病和死亡为特征 ,其病因和发病机理不明 ,尚缺乏改变其自然病程的有效治疗。Ｄ-青霉胺 (Ｄ -Ｐｅｎ)具有干扰胶原的分子交联和可能的免疫调节作用 ,认为是ＳＳｃ的潜在治疗方法
Systemic sclerosis (SSc) is a multisystem disorder of connective tissue characterized clinically by fibrosis of the skin, involvement of organs and considerable morbidity and mortality, and its etiology and pathogenesis are unknown and its natural history is lacking Effective treatment. D-Penicillamine (D-Pen) has the potential to interfere with the molecular cross-linking of collagen and possible immunomodulatory effects and is considered as a potential treatment for SSc