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目的:制备多柔比星磁性葡聚糖微球并检测其特性。方法:采用吸附法制备多柔比星磁性葡聚糖微球。高倍显微镜观察微球粒径大小及形态,紫外分光光度法检测微球中多柔比星的含量,测定微球磁吸附率,计算求和值 S,确定最佳投料比(药物:载体),绘制药物微球体外释放曲线。结果:制备的多柔比星磁性葡聚糖微球最佳投料比为1:15,磁吸附率为100%。微球外形圆整,分散性好。多柔比星30 min 释放28%;60min 释放45%;6h 释放65%。结论:制备的多柔比星磁性葡聚糖微球缓释性好,磁响应性强,可作为一种治疗顽固性疼痛的靶向神经损毁剂。
Objective: To prepare doxorubicin magnetic dextran microspheres and test its properties. Methods: Preparation of doxorubicin magnetic dextran microspheres by adsorption method. Microscope was used to observe the particle size and morphology of the microspheres. The content of doxorubicin in the microspheres was determined by ultraviolet spectrophotometry. The magnetic adsorption rate of the microspheres was determined. The summation value S was calculated to determine the optimal ratio of drug to drug: Draw the in vitro release curve of drug microspheres. Results: The best dosages of doxorubicin-loaded dextran microspheres were 1:15 and the magnetic adsorption was 100%. Microspheres shape round, decentralized. Doxorubicin released 28% after 30 min; 45% after 60 min; 65% after 6 h. CONCLUSION: The preparation of doxorubicin-loaded dextran microspheres has good slow-release properties and strong magnetic response and can be used as a targeted nerve damage agent for refractory pain.