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目的；人体组织纤维蛋白溶解酶原酶（ｔ－ＰＡ）治疗不同病因脑梗塞的疗效的再探讨。方法：以颈动脉和心脏Ｄｏｐｐｌｅｒ超声和数字式血管造影（ＤＳＡ）的检查结果为依据作分组对比分析ｒｔ－ＰＡ的治疗效果。结果：ｒＴ－ＰＡ治疗后２４ｈ症状改善与预后有关。颈动脉粥样硬化性完全梗塞和严重狭窄组病例溶栓起效时间明显推迟（Ｐ＜０．０５）。３个月后颈动脉完全梗塞组６８．７５％有严重神经系统后遗症。结论：颈动脉粥样硬化性梗塞和严重狭窄是影响溶栓治疗预后的一个重要因素。
Objective To investigate the therapeutic effect of human tissue fibrinolytic enzyme (t-PA) on cerebral infarction with different etiology. Methods: The therapeutic effects of rt-PA were compared and analyzed according to the results of carotid and cardiac Doppler ultrasound and digital angiography (DSA). Results: 24h after rT-PA treatment of symptoms and prognosis. The onset of thrombolysis was significantly delayed in patients with complete carotid atherosclerosis and severe stenosis (P <0.05). After 3 months, 68.75% of patients with complete carotid artery infarction had severe neurological sequelae. Conclusion: Carotid artery atherosclerosis infarction and severe stenosis is an important factor affecting the prognosis of thrombolytic therapy.