中毒性休克综合征(TSS)是一种突然发热、发疹性疾病,常伴有心、肾功能衰竭、成人呼吸窘迫综合征及休克等多器官系统衰竭。TSS 治疗的关键在于早期确诊,病人通常有葡萄球菌感染病灶,如手术伤口感染、软组织脓肿,或者妇女经期使用阴道棉塞等情况。诊断 TSS 的主要依据(标准)是急性发热、猩红热样疹、指尖、趾尖、掌面和足底的进行性脱皮及具有直立性头晕或晕厥或明显休克为特征的低血压。附加诊断依据是有累及3个以上器官系统的证据,如血液、胃肠、神经、心血管、肝、肾或肌肉等器官系统。TSS 病人的治疗可分为三期,(1)急性期:处理休克、脱水和多器官系统衰竭,首先应去除感染病灶,静脉给予抗生素,补给晶体与胶体液,第1h Toxic shock syndrome (TSS) is a sudden fever, rash disease, often accompanied by heart and kidney failure, adult respiratory distress syndrome and multiple organ system failure such as shock. The key to TSS treatment is early diagnosis. Patients usually have staphylococcal infection, such as surgical wound infection, soft tissue abscess or vaginal tamponade for women during menstruation. The main criteria (criteria) for diagnosing TSS are acute fever, scarlet fever rash, progressive peeling of the fingertips, tiptoe, palmar and plantar, and hypotension characterized by erection or fainting or overt shock. Additional diagnosis is based on evidence of involvement of more than three organ systems such as blood, gastrointestinal, neurological, cardiovascular, liver, kidney or muscle organ systems. TSS patients can be divided into three phases, (1) acute phase: the treatment of shock, dehydration and multiple organ system failure, the first removal of infected lesions, intravenous antibiotics, supplies of crystal and colloid fluid, 1h