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以非放射性(Dig—HBV—DNA 探针)分子杂交技术,检测了银川地区405例 HBsag携带人群中的 HBV—DNA。阳性率为34.81%(男性40.32%高于女性30.14%,P<0.05),且随年龄的增长而极急速地下降(P<0.005),回汉民族间无明显差异。HBsAg 的滴度与HBV—DNA 的检出率呈正相关(γ_s=0.999,P<0.01)HBsAg 的滴度至≥1:256时,HBV—DNA 的检出率可高达100%。作者等认为;以 HBsAg 的定量滴度来判定其传染性有一定的参考价值;滴度在1:64～1:128时需加强治疗管理,≥1:256时应视为病毒复制的标志,并具有较强的传染性。
The non-radioactive (Dig-HBV-DNA probe) molecular hybridization technique was used to detect HBV-DNA in 405 HBsAg-carrying population in Yinchuan. The positive rate was 34.81% (40.32% for males and 30.14% for females, P <0.05), and declined rapidly with age (P <0.005). There was no significant difference between Hui and Han peoples. The titer of HBsAg was positively correlated with the detection rate of HBV-DNA (γ_s = 0.999, P <0.01). The detection rate of HBV-DNA was 100% when the titer of HBsAg was ≥1: 256. The authors believe that; to HBsAg quantitative titer to determine its infectivity have a certain reference value; titers in the 1: 64 ~ 1: 128 need to strengthen the treatment management, ≥ 1: 256 should be regarded as a sign of viral replication, And has a strong contagious.