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Objective:To determine the encephalic region correlated with epilepsy by manganese-enhanced MRI(MEMRI)and determine the correlation of epilepsy with calcium overloading.Methods:The cats were divided into two groups.The first group underwent EEG examination and ethological observation.The second group underwent MEMRI measurement.Signal enhanced encephalic regions were sectioned.Results:The achievement ratio of convulsive cats intramusclelarly injected with PTZ was 80%.MEMRI showed diffuse signal enhancement in the cerebral cortex of the cats with generalized tonic-clonic convulsive seizures compared with control animals.The enhancement rate of frontal-parietal-occipital lobe was 34.6% and 22.9% in temporal lobe compared with the control groups.Signal enhancement on frontal-parietal lobe persisted for 24 h after epileptic seizures were induced.The neurons of enhanced encephalic regions showed obvious degeneration and necrosis.Conclusion:Seizures can be induced in cats by intramuscular injection of PTZ(55 mg/kg).Frontal-parietal lobe is the correlated encephalic regions of epilepsy.MEMRI plays an important role in localizing and revealing pathogenesis of epileptic seizures.
Objective: To determine the encephalic region correlated with epilepsy by manganese-enhanced MRI (MEMRI) and determine the correlation of epilepsy with calcium overloading. Methods: The cats were divided into two groups.The first group underwent EEG examination and ethological observation. Second group underwent MEMRI measurement. Signal enhanced encephalic regions were sectioned. Results: The achievement ratio of convulsive cats intramusclelarly injected with PTZ was 80% .MEMRI showed diffuse signal enhancement in the cerebral cortex of the cats with generalized tonic-clonic convulsive seizures compared with control animals.The enhancement rate of frontal-parietal-occipital lobe was 34.6% and 22.9% in temporal lobe compared with the control groups. Signaling enhancement on frontal-parietal lobe persisted for 24 h after epileptic seizures were. The neurons of enhanced encephalic regions showed obvious degeneration and necrosis. Confusion: Seizures can be induced in cats by intramuscular in jection of PTZ (55 mg / kg). Frontal-parietal lobe is the correlated encephalic regions of epilepsy. MEMI plays an important role in localizing and revealing pathogenesis of epileptic seizures.