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目的 探讨细胞凋亡与胃癌发生的关系。方法 检测 3 0例慢性浅表性胃炎 (CSG )、3 0例肠化生 (IM )、18例不典型增生 (Dys)及 2 5例胃腺癌 (GAC)组织中细胞凋亡的情况。 结果 CSG、IM、Dys及GAC组的凋亡指数 (AI)分别为 3 .0～ 3 4 .0、2 .0～ 14 .0、0 .1～ 5 .0和 0～ 2 .0 ,中位值分别为 15 .5、9.0、2 .0和 0 .5。CSG组AI高于IM组 (u =2 .3 1,P <0 .0 5 ) ,IM组高于Dys组(u =5 .2 3 ,P <0 .0 1) ,Dys组与GAC组的AI分级比较无显著性差异 (u =0 .64 ,P >0 .0 5 )。从CSG到IM、Dys及GAC组 ,AI分级与胃粘膜病变程度呈显著负相关 (γ =-0 .83 4 7,P <0 .0 1)。在CSG组 ,AI分级与胃粘膜炎症程度呈显著正相关 (γ =0 .5 62 6,P<0 .0 1)。结论 细胞凋亡在胃癌的发生过程中起着重要作用。
Objective To investigate the relationship between apoptosis and gastric carcinogenesis. Methods The apoptosis of 30 cases of chronic superficial gastritis (CSG), 30 cases of intestinal metaplasia (IM), 18 cases of atypical hyperplasia (Dys) and 25 cases of gastric adenocarcinoma (GAC) were examined. Results The apoptosis index (AI) of CSG, IM, Dys and GAC groups were 3.0 ~ 3.4 ± 0.2, 0.0 ~ 14.0, 0.1 ~ 5.0 and 0 ~ 2.0, respectively The bit values are 15.5, 9.0, 2.0, and 0.5, respectively. AI in CSG group was higher than that in IM group (u = 2.31, P <0.05), IM group was higher than Dys group (u = 5.23, P <0.01) AI grade no significant difference (u = 0.64, P> 0.05). From CSG to IM, Dys and GAC, there was a significant negative correlation between AI grade and the degree of gastric mucosal lesions (γ = -0.88347, P <0.01). In the CSG group, there was a significant positive correlation between AI grade and the degree of gastric mucosal inflammation (γ = 0.56 6, P <0.01). Conclusion Apoptosis plays an important role in the carcinogenesis of gastric cancer.